I’m The Only One With Genius DNA - Chapter 149

I’m The Only One With Genius DNA chapter 149
< Ministry of Food and Drug Safety (4)>

Song Jong-ho’s condition was quite serious.

Although he did not tell Ryu Young-joon, Professor Shin Jung-joo sighed inside while looking at the interview records.

– The voices made them do it, but they said they eat red when they stop studying. The Buddhist monks who hit the candle removed a chip from the temple, and the chip was planted, so the sound leaked from the chip, dripping with water.

– Wearing hoodies, the car was bumpy and beepy, and monks had a runny nose. He left me with difficulty. If I was strong in the afternoon after taking a bath, I put on a sunset hat and rubbed it thoroughly.

It is written by Song Jong-ho.

Logical geocompatibility.

It is one of the typical symptoms of chronically advanced schizophrenia.

A language breakdown that has no point leading to one, fragmented and meaningless logic unfolds everywhere, making it impossible to understand the point at all.

At this rate, it’s been quite a bit progressed.

In addition, there are also “circumstantial” and “neologism”.

It is to spin around the issue and make nonsense and come up with words that do not exist.

Both are typical of serious schizophrenia.

“I’ve prescribed a combination of clozapine, risperidone, and SSRI, an antidepressant, is that okay?”

Shin Jung-ju talked to herself while looking at the prescription record.

The prescription came at the strong request of his guardian, Dr. Song Ji-hyun.

Originally, it was only intended to prescribe clozapine.

However, Song Ji-hyun intervened in prescribing drugs by pushing into the World Biological Psychiatric Federation’s guidelines and related papers.

It was a slightly bold prescription for Shin, but there was nothing I could do anything about it.

“Honestly, I think you know more about schizophrenia than I do.”….”

He is a famous scientist and pharmacist who originally develops new drugs, so he can know well about new drugs.

Considering that, however, Song Ji-hyun’s knowledge was unique. Perhaps knowledge of schizophrenia is one hand in Korea.

“These days, patients have more ways to study, and cancer patients have almost as much anti-cancer knowledge as doctors.Derney.”

Professor Shin Jung-joo threw his tongue out.

***

“Jong Ho, let’s take medicine.”

Song Ji-hyun, who returned home, took medicine and held it out to her brother.

It’s a war every time I drugged you.

It is almost impossible to control a man with a female body, who gained weight up to 120 kilograms due to his 190-cm-long body and drug side effects.

The language has been broken down, so conversations cannot be communicated and are no match for physical strength.

My father, who could control some power, was not home today, and Song Ji-hyun had to feed him alone.

Of course, this has happened more than once.

Song Ji-hyun pushed pills into her mouth with her fingers and tried to feed them with water, just as the disobedient animals were coaxed and meditated.

“Ugh!”

However, when the medicine went into his mouth, Song quickly spat it out.

“It’s better to eat this.”

Song Ji-hyun put the dropped medicine back in her mouth, and Song Jong-ho spit it out again.

Saliva and water were all over the place and after struggling for half an hour, managed to swallow a pill.

I have to eat risperidone and SSRI.….’

The treatment for schizophrenia is a dopamine inhibitor.

Modern medicine has found one important fact after intensively studying schizophrenia.

It was that dopamine was abnormally over-expressed in the brain of a schizophrenic patient.

This huge amount of dopamine causes various problems in the brain.

Therefore, suppressing the dopamine may reduce the disease.

The prediction was right, and the administration of dopamine inhibitors in early schizophrenia patients could significantly capture the condition.

A great advance in psychiatry.

Patients have less hearing or delusions and recover their cognitive abilities. You can distinguish between the mental world where hallucinations or delusions occur and the mental world when you are in normal condition.

From then on, if the patient manages his or her own disease by taking medication steadily, he or she can live his or her daily life to a certain extent while holding the disease like diabetes.

“Let’s eat this, too.”

“Let’s eat this, too.”

Song Ji-hyun fed her risperidone. Fortunately, it didn’t take too long this time.

Both clozapine and risperidone are dopamine inhibitors. It is a treatment used for combined administration of severe patients.

But this treatment is cruel.

Song Ji-hyun swallowed her saliva.

I saw Song Jong-ho’s eyes after taking medicine.

My heart suddenly became heavy.

Dopamine is a hormone of pleasure.

It is a hormone that makes you feel thrilled, usually released when you are happy and happy.

To suppress the dopamine means to put the patient in a great sense of helplessness and depression.

“…I just need to eat SSRI.”

Song Ji-hyun took out one more pill.

SSRI. Selective Serotonin Reuptake Inhibitors의 약자다. It means selective serotonin reuptake inhibitor.

This medicine is an antidepressant.

Song Ji-hyun took out the SSRI and took it to her brother’s mouth.

Snap!

Song Jong-ho cut her hand hard.

“Ugh……”

“You’ll feel better if you eat this. It’s okay. Come here.”

Song Ji-hyun picked up the medicine that fell on the floor again.

“Die!”

Song Jong-ho took out the medicine again. This time, his fingertips also hit Song Ji-hyun’s cheek.

“Argh!”

It is the size of Song Ji-hyun’s head. Song Ji-hyun’s head turned quickly even though he just brushed against her.

“…….”

She rubbed her cheek.

I picked up the dropped medicine again.

***

“What do you think?”

Ryu Young-joon asked Rosaline as he took the sample from the centrifuge.

The sample contained a cell solution.

When placed in a centrifuge and separated by applying strong gravity, the substances inside the cell solution are separated by weight.

The heavier one goes down.

After about an hour of separation, there is a layer inside the liquid.

It’s like leaving muddy water for a long time causes heavy sand to sink down and separate from the water.

It’s done.

Rosaline said.

– Separate the light blue part of the 13th layer from the bottom. There’s mitochondria in there.

“13th from the bottom?”

Ryu Young-joon squinted at the 50-mL Falcon plastic tube.

“There are 13 separate layers in this sample?”

The separation boundary of the “layer” was not clear because it was almost transparent and almost colorless.

When Ryu Young-joon frowned, Rosaline stepped in.

Oh, not that way. Oh, man. The human eye can’t tell that from different layers.

Rosaline popped out of Ryu Young-joon’s

I can’t. I’ll point it out of you.

She poked her finger into the underside of the Falcon tube.

– This part.

“There’s a separate floor here?”

Do you want me to separate them if it’s too hard? Give me a hand control and I’ll pick you.

“That’s enough, dude. Hey, I’ve been doing biological experiments for 10 years.”

“That’s enough, dude. Hey, I’ve been doing biological experiments for 10 years.”

Ryu Young-joon said as if his pride was hurt.

Then try it. I’ll coach you.

Ryu took the pipette and extracted the solution and carefully separated the liquid in the target location.

“Done?”

I got some impurities, but I did a good job.

“The impurities will be removed in the process of incubation anyway.”

– That’s right.

“But how do you incubate mitochondria?”

I’ll let you know from now on. It’s not that difficult. Mitochondria were originally separate creatures.

The concept of ‘living things’ is quite vague.

Usually, ‘living things’ assume a singular object with a single identity.

But even the most basic unit, “cells,” actually have a large collection of creatures in them.

The most representative is mitochondria.

About 2.1 billion years ago.

There was a unique-looking prokaryotic cell. It was much bigger than other creatures, and one day it accidentally absorbed a bacteria.

Bacteria have not been digested as food inside the prokaryotic cells or destroyed as pathogens.

Instead, it came to a very unusual conclusion that bacteria co-exist inside the body of prokaryotic cells.

It was a moment when two different micro-world creatures joined hands.

Common ancestor of ‘animal’ and ‘plant’ that encompasses all insects and fish, mammals, reptiles, outer and inner seed plants and ferns.

It was the moment when the Earth’s greatest miracle of biology was born, the Eukaryote.

It later absorbed them into the gene, suffering numerous viral infections.

Viruses helped the cells evolve by symbiosis with eukaryotic cells in the form of transphosons.

A cell is in the same state as a collection of numerous living things.

And at some point, eukaryotic cells no longer live alone as single cells.

They have invented a ‘cellular society’ in which groups are united.

It was time for multicellular life to emerge.

Since then, as the ozone layer has formed and the amount of ultraviolet light reaching the surface has decreased, multicellular organisms have made inroads into the land.

It was about 500 million years ago.

All life on the ground now is descended from it.

It’s been part of eukaryotic cells for 2.1 billion years. It must have lost a lot of its function as an independent creature. However, if you fix a few things, you can grow them.

“Okay, let’s do it. What should I do?

– First, let’s recreate the environment in which mitochondria lived as bacteria.

Rosaline said.

– We’re going to recreate the depths of the ocean about 2.4 billion years ago. Let’s start with the PBS solution. First put 400 grams of sodium in the 1X PBS container on the shelf.

“400 grams of sodium.”

– Then we need to remove oxygen from there. At that time, oxygen began to be generated in the sea, but the amount was small and it was not enough for life to use in response to minerals such as marble and iron in the sea.

“All right…….”

– And we need to increase the methane concentration. Can you make it this far?

“And then what?”

– Now we need to put the genes in the mitochondria. Mitochondria have lost a lot of their genes in the last 2.1 billion years. It’s like importing things from the genes of eukaryotic cells. Now let’s revitalize the missing domestic economy for the mitochondria.

“You’re getting better at talking. I’ve just been craving domestic economy jokes.”

When you use it somewhere, you have to tell them it’s mine.

***

Mitochondria were incubated for four days.

It has grown in huge quantities. One liter of the culture solution is full.

He took pictures with an electron microscope and recorded O.D. values.

The fact that mitochondria were successful in restoring and cultivating them into primitive bacteria is enough to decorate the science cover.

It may not be available in medicine or industry, but it means a lot academically.

However, Ryu Young-joon has yet to write a paper.

Because I still have a lot of work to do with this.

Because I still have a lot of work to do with this.

“A total of 107 genetic samples requested.”

Eisen’s DNA synthesis team sent a large amount of freeze-dried DNA.

“But where are you going to use all this DNA……?”

The employee who delivered it asked wonderfully.

“We’re going to develop a new treatment. The details are still a secret, and I’ll leave it to the researchers when I get some results. It’s a pilot experiment, so I’m doing it myself.”

Ryu Young-joon said.

The process of inserting genes into the mitochondria used tectropores.

It is a technology that tears a cell membrane with electric stimulation and then inserts DNA.

Almost all microorganisms can’t withstand this damage and die, but it doesn’t matter.

We can restore the surviving ones and re-cultivate them. All of those second-cultured cells have new genes.

Now let’s do an animal experiment.

Rosaline said.

He received a mouse research model for schizophrenia at the Eisen Research Support Center.

It is a rat that manipulates dopamine expression genes to act similar to suffering from schizophrenia.

If successful, the first step toward clinicians will be successful.

If successful, the first step toward clinicians will be successful.

To get clinical approval for this crazy new drug, you’ll have to have a lot of safety-proven animal testing data.….’

Ryu Young-joon looked quietly at the cage containing 30 mice.